An Evaluation of Systemic Vancomycin Dosing in Obese Patients
نویسندگان
چکیده
We retrospectively identified 67 patients with severe or morbid obesity (body mass index ≥35 kg/m(2)) who had received intravenous vancomycin at our institution. We observed that an initial dose of 45 to 65 mg/kg vancomycin per day based upon ideal body weight rather than actual body weight was more predictive of initial trough concentrations between 15 and 20 mcg/mL.
منابع مشابه
Multicenter evaluation of vancomycin dosing: emphasis on obesity.
BACKGROUND There is a paucity of data available regarding the dosing of antimicrobials in obesity. However, data are available demonstrating that vancomycin should be dosed on the basis of actual body weight. METHODS This study was conducted at 2 tertiary care medical centers that did not have pharmacy-guided vancomycin dosing programs or other institutional vancomycin dosing policies or prot...
متن کامل393Vancomycin Dosing in Obese Patients
Background. Current guidelines for systemic vancomycin dosing recommended using actual body weight (ABW) regardless of body mass index (BMI). We sought to evaluate the effect of this dosing strategy in obese patients with BMI ≥35. Methods. Retrospective cohort study of patients ≥18 years old with a BMI ≥35 hospitalized between January 1, 2011 and December 31, 2013 with at least 3 doses of intra...
متن کاملA Prospective Study to Assess Vancomycin Serum Concentrations in Pediatric Patients with Current Dosing Guidelines
Concerns about increasing bacterial resistance to vancomycin, have caused the adult treatment guidelines to recommend higher trough concentrations based on the type and location of infectious disease. Although these recommendations are not specific to children, the values can be extrapolated. This prospective study was designed to evaluate efficacy of current vancomycin dosing recommendations t...
متن کاملA Prospective Study to Assess Vancomycin Serum Concentrations in Pediatric Patients with Current Dosing Guidelines
Concerns about increasing bacterial resistance to vancomycin, have caused the adult treatment guidelines to recommend higher trough concentrations based on the type and location of infectious disease. Although these recommendations are not specific to children, the values can be extrapolated. This prospective study was designed to evaluate efficacy of current vancomycin dosing recommendations t...
متن کاملVancomycin Dosing Considerations in a Real-World Cohort of Obese and Extremely Obese Patients.
STUDY OBJECTIVE To compare the effects of empiric vancomycin dosing regimens on attainment of optimal target trough concentrations in obese (body mass index [BMI] 30-40 kg/m(2) ) and extremely obese (BMI ≥ 40 kg/m(2) ) patients. DESIGN Retrospective cohort study. DATA SOURCE National Veterans Affairs standardized databases. PATIENTS A total of 263 obese and 71 extremely obese (actual body...
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